Live fate-mapping of joint-associated fibroblasts visualizes expansion of cell contributions during zebrafish fin regeneration
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چکیده
منابع مشابه
Ras controls melanocyte expansion during zebrafish fin stripe regeneration.
Regenerative medicine for complex tissues like limbs will require the provision or activation of precursors for different cell types, in the correct number, and with the appropriate instructions. These strategies can be guided by what is learned from spectacular events of natural limb or fin regeneration in urodele amphibians and teleost fish. Following zebrafish fin amputation, melanocyte stri...
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The blastema is a mass of progenitor cells that enables regeneration of amputated salamander limbs or fish fins. Methodology to label and track blastemal cell progeny has been deficient, restricting our understanding of appendage regeneration. Here, we created a system for clonal analysis and quantitative imaging of hundreds of blastemal cells and their respective progeny in living adult zebraf...
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Many fish and salamander species regenerate amputated fins or limbs, restoring the size and shape of the original appendage. Regeneration requires that spared cells retain or recall information encoding pattern, a phenomenon termed positional memory. Few factors have been implicated in positional memory during vertebrate appendage regeneration. Here, we investigated potential regulators of ante...
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*Address correspondence to: Leonor Santos-Ruiz. Departamento de Biología Celular y Genética, Facultad de Ciencias, Universidad de Málaga, Spain. e-mail: [email protected] ABSTRACT Teleost fins can be structural and functionally restored after severe injuries or partial amputation through a process of epimorphic regeneration, which requires an acute temporal and spatial control of basic cell events...
متن کاملThe art of fin regeneration in zebrafish
The zebrafish fin provides a valuable model to study the epimorphic type of regeneration, whereby the amputated part of the appendage is nearly perfectly replaced. To accomplish fin regeneration, two reciprocally interacting domains need to be established at the injury site, namely a wound epithelium and a blastema. The wound epithelium provides a supporting niche for the blastema, which contai...
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ژورنال
عنوان ژورنال: Development
سال: 2017
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.155655